Protein Details: Potassium voltage-gated channel protein Shaker

Protein ID

ICDB_Pro_0313

Protein Name

Potassium voltage-gated channel protein Shaker

Gene Name

Sh; mns; CG12348

Organism

Drosophila melanogaster (Fruit fly)

Length

655 amino acids

AlphaFoldDB

AF-P08510-F1-model_v4.pdb

Function

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Forms rapidly inactivating tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient and may contribute to A-type currents. Plays a role in the regulation of sleep need or efficiency. Plays a role in sexual behavior; where it is important for male sex discrimination

Sequence

MAAVAGLYGLGEDRQHRKKQQQQQQHQKEQLEQKEEQKKIAERKLQLREQQLQRNSLDGYGSLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAINKFREDEGFIKEEERPLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVESTPGLTETHPGRSAVAPFLGAQQQQQQPVASSLSMSIDKQLQHPLQQLTQTQLYQQQQQQQQQQQNGFKQQQQQTQQQLQQQQSHTINASAAAATSGSGSSGLTMRHNNALAVSIETDV

PDB Structures

1HO2 1HO7 7SIP 7SJ1

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in mushroom body (at protein level); this overlaps with expression of qvr/quiver/sleepless and nicotinic acetylcholine receptor (nAChRs) proteins also involved in sleep regulation. Expressed in the adult brain. Enriched in the mushroom body; anterior optic tubercle; superior protocerebrum; antennal nerve and visual projection neuron fibers projecting into the lobula plate of the optic lobe.

DOI ID

10.1126/science.2441471; 10.1002/j.1460-2075.1987.tb02665.x; 10.1002/j.1460-2075.1988.tb02917.x; 10.1038/331137a0; 10.1126/science.287.5461.2185; 10.1186/gb-2002-3-12-research0083; 10.1186/gb-2002-3-12-research0080; 10.1016/0092-8674(87)90494-6; 10.1016/0896-6273(88)90192-4; 10.1038/331143a0; 10.1126/science.1086763; 10.1038/nature03486; 10.1093/glycob/cwm097; 10.1371/journal.pone.0030799; 10.1016/s0006-3495(02)75640-3

RefSeq

NP_001162788.1 [P08510-5]; NP_001188668.1 [P08510-3]; NP_001245727.1 [P08510-9]; NP_001259665.2 [P08510-2]; NP_523393.3 [P08510-2]; NP_728120.1 [P08510-7]; NP_728122.1 [P08510-3]; NP_728123.1 [P08510-1]; NP_728124.1 [P08510-5]; NP_996497.1 [P08510-6]; NP_996498.2 [P08510-3]